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Posted by: thepinetree on 03/31/2020 09:40 PM Updated by: thepinetree on 03/31/2020 09:40 PM
Expires: 01/01/2025 12:00 AM

MIT-Based Team Works on Rapid Deployment of Open-Source, Low-Cost Ventilator

Cambridge, MA...One of the most pressing shortages facing hospitals during the Covid-19 emergency is a lack of ventilators. These machines can keep patients breathing when they no longer can on their own, and they can cost around $30,000 each. Now, a rapidly assembled volunteer team of engineers, physicians, computer scientists, and others, centered at MIT, is working to implement a safe, inexpensive alternative for emergency use, which could be built quickly around the world.

The team, called MIT E-Vent (for emergency ventilator), was formed on March 12 in response to the rapid spread of the Covid-19 pandemic. Its members were brought together by the exhortations of doctors, friends, and a sudden flood of mail referencing a project done a decade ago in the MIT class 2.75 (Medical Device Design). Students and faculty working in consultation with local physicians designed a simple ventilator device that could be built with about $100 worth of parts, although in the years since prices have gone up and the device would now cost $400 to $500 in materials. They published a paper detailing their design and testing, but the work ended at that point. Now, with a significant global need looming, a new team, linked to that course, has resumed the project at a highly accelerated pace.

The key to the simple, inexpensive ventilator alternative is a hand-operated plastic pouch called a bag-valve resuscitator, or Ambu bag, which hospitals already have on hand in large quantities. These are designed to be operated by hand, by a medical professional or emergency technician, to provide breaths to a patient in situations like cardiac arrest, until an intervention such as a ventilator becomes available. A tube is inserted into the patient’s airway, as with a hospital ventilator, but then the pumping of air into the lungs is done by squeezing and releasing the flexible pouch. This is a task for skilled personnel, trained in how to evaluate the patient and adjust the timing and pressure of the pumping accordingly.

The innovation begun by the earlier MIT class, and now being rapidly refined and tested by the new team, was to devise a mechanical system to do the squeezing and releasing of the Ambu bag, since this is not something that a person could be expected to do for any extended period. But it is crucial for such a system to not damage the bag and to be controllable, so that the amount of air and pressures being delivered can be tailored to the particular patient. The device must be very reliable, since an unexpected failure of the device could be fatal, but as designed by the MIT team, the bag can be immediately operated manually.

The team is particularly concerned about the potential for well-meaning but inexperienced do-it-yourselfers to try to reproduce such a system without the necessary clinical knowledge or expertise with hardware that can operate for days; around 1 million cycles would be required to support a ventilated patient over a two-week period. Furthermore, it requires code that is fault-tolerant, since ventilators are precision devices that perform a life-critical function. To help curtail the spread of misinformation or poorly-thought-out advice, the team has added to their website verified information resources on the clinical use of ventilators and the requirements for training and monitoring in using such systems. All of this information is freely available at

“We are releasing design guidance (clinical, mechanical, electrical/controls, testing) on a rolling basis as it is developed and documented,” one team member says. “We encourage capable clinical-engineering teams to work with their local resources, while following the main specs and safety information, and we welcome any input other teams may have.”

The researchers emphasize that this is not a project for typical do-it-yourselfers to undertake, since it requires specialized understanding of the clinical-technical interface, and the ability to work in consideration of strict U.S. Food and Drug Administration specifications and guidelines.

Such devices “have to be manufactured according to FDA requirements, and should only be utilized under the supervision of a clinician,” a team member said. “The Department of Health and Human Services released a notice stating that all medical interventions related to Covid-19 are no longer subject to liability, but that does not change our burden of care.” he said. “At present, we are awaiting FDA feedback” about the project. “Ultimately, our intent is to seek FDA approval. That process takes time, however.”

The all-volunteer team is working without funding and operating anonymously for now because many of them have already been swamped by inquiries from people wanting more information, and are concerned about being overwhelmed by calls that would interfere with their work on the project. “We would really, really like to just stay focused,” says one team member. “And that’s one of the reasons why the website is so essential, so that we can communicate with anyone who wants to read about what we are doing, and also so that others across the world can communicate with us.”

“The primary consideration is patient safety. So we had to establish what we’re calling minimum clinical functional requirements,” that is, the minimum set of functions that the device would need to perform to be both safe and useful, says one of the team members, who is both an engineer and an MD. He says one of his jobs is to translate between the specialized languages used by the engineers and the medical professionals on the team.

That determination of minimum requirements was made by a team of physicians with broad clinical backgrounds, including anesthesia and critical care, he says. In parallel, the group set to work on designing, building, and testing an updated prototype. Initial tests revealed the high loads that actual use incurs, and some weaknesses that have already been addressed so that, in the words of team co-leads, “Even the professor can kick it across the room.” In other words, early attempts focused on super “makability” were too optimistic.

New versions have already been fabricated and are being prepared for additional functional tests. Already, the team says there is enough detailed information on their website to allow other teams to work in parallel with them, and they have also included links to other teams that are working on similar design efforts.

In under a week the team has gone from empty benches to their first realistic tests of a prototype. One team member says that in the less than a week full they have been working, motivated by reports of doctors already having to ration ventilators, and the intense focus the diverse group has brought to this project, they have already generated “multiple theses worth” of research.

The cross-disciplinary nature of the group has been crucial, one team member says. “The most exciting times and when the team is really moving fast are when we have an a design engineer, sitting next to a controls engineer, sitting next to the fabrication expert, with an anesthesiologist on WebEx, all solid modeling, coding, and spreadsheeting in parallel. We are discussing the details of everything from ways to track patients’ vital signs data to the best sources for small electric motors.”

The intensity of the work, with people putting in very long hours every day, has been tiring but hasn’t dulled their enthusiasm. “We all work together, and ultimately the goal is to help people, because people’s lives understandably hang in the balance,” he said.

The team can be contacted via their website.

Source = David L. Chandler | MIT News

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Amazing Americans are doing Amazing things!
Posted on: 2020-03-31 22:09:31   By: Anonymous
Thank you to all our front line heroes!

Hello ALl,

Coronavirus Task Force, Briefing March 30, 2020:

Alex Azar - Health And Human Services Secretary

More than 1,000,000 samples tested to date. A number that no other country has reached.

We're now testing more than 100,000 samples a day. Also a level that no other country has reacheed.

20 different emergency testing options. The number of options are growing every day.

Secured 30,000,000 tablets from Sandoz's and 1,000,000 tablets from Bayer of Hydroxychloroquine and Chloroquine which are potential Covid-19 treatments.

[FDA] Authorized Batels new decontamination machines which can each sterilize 1,000's of essential N95 masks for re-use everyday.

More people report after President Trump.

President Trump

Teva Pharmaceutical's is also donating 6,000,000 doses of Hydroxychloroquine to U.S. Hospitals.

Battelle's new machine to disinfect N95 masks was fast tracked for approval by the FDA. Each machine can disinfect 120,000 masks per day. They have 2 in Ohio, 1 in New York and 1 will soon be shipped to Seattle, Washington and also to Washington D.C.

In New York, the 1,200 bed field hospital was completed in 3 1/2 days at the Javits Center, [can be expanded to 2,900].

U.S Navey Sgip Comfort Arrived today equipped with 12 operating rooms and1,000 hospital beds.

Work has begun on additional temporary hospital sites including a 600 bed capacity nursing home facility in Brooklyn and numerous floors of high rise building on Wall Street.

The Army Corp Of Engineers has awarded contracts for the construction of alternate care facilities also at the State University at Stony Brook, State University Old Westbury and the West Chester Community Center

Sending 60 Ambulances to New York City today. Up to 190 to follow at different locations.

FEMA and HHS already delivered 11.6 million N95 masks, 26 million surgical masks, 5.3 million face shields, 4.4 million surgical gowns, ans 22 million gloves.

Ford and General Electric Health Care will produce 50,000 ventilators and they are going to be doing it in less than 100 days. On top of that we have other companies that are doing ventilators including General Motors. As we outpace what we need we will be sending them to Italy, France, Spain, and other countries as we can.

Mile Lindell, My Pillow CEO

My Pillow will be producing cotton face masks. In 3 days they were producing up to 10,000 a day. By Friday they want to produce up to 50,000 a day.

Darius Adamczyk, Honeywell CEO

Honeywell announced a few days ago a start up of a new manufacturing facility in Rhode Island. They are going to hire 500 employees, they have already 200 on board and we are going to be starting the production of N95 masks whthin the next 2 weeks.

Furthermore today we are annoumcing the start up of another manufacturing facility in Arizona. We are going to be hiring another 500 people. We will be starting up production at that facility by the middle of May. So, in total we've doubled our production of N95 masks already, it's going to double the next 60 days, and then withing the 90 days we are going to have a 5X the capacity we do today.

Debra Waller, Jockey International CEO

We are expecting to deliver 30 to 50,000 hospital gowns per week.

In addition, this week, we are also donating 10,000 units of scrubs to the front lines Doctors and Nurses at the Javits Convention Center in New York City,

David Taylor, Procter & Gamble CEO

Our people worked together to transform out plants, to make things that they have never made before like hand sanitizers and facial masks. Some of these are already getting to National, State, and Local agencies. Some are in the Hospitals already.

Gregory Hayes, United Technologies CEO

As one of the largest defense contractors and some of the best technology we're using it to try and solve some real world problems . Today we are working with the Air Force to try and help pilots, as they are moving medical evacuee's with the Covid-19 virus, such that they can be protected and that the patients can be protected. Working with Logistics [moving "stuff" around the country] will coordinate all of these activities. Last week donated about 90,000 of personal pieces of equipment to FEMA. Next week we'll have another almost 1,000,000.

We are also, this week, beginning the manufacture face shields. We will be able to produce approximately 10,000 shields in the next 4 weeks.

If your news source has not told you about the above, you may want to consider a different source for your new because they are not keeping you informed!

Hope this helps.

[Reply ]

    Re: Amazing Americans are doing Amazing things!
    Posted on: 2020-04-01 08:37:43   By: Anonymous
    Posters here often bash what they consider the liberal east and west coasts. (A caveat, though, there are more independent voters in places like Massachusetts than any other party.) Very proud of both, the seats of quality higher education and where novel, new ideas originate.

    [Reply ]

No Subject
Posted on: 2020-04-01 09:49:21   By: Anonymous
Aha! Those damn flatlanders have gone and done something useful. We want their technology and money — but please stay away from us.

[Reply ]

Posted on: 2020-04-10 09:50:44   By: Anonymous
I clearly did not understand to what this platform of the isum is all about. I tried to open it online but it shows temporarily unavailable online. Can anyone suggest me any alternative platform to this?

[Reply ]

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