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Posted by: thepinetree on 01/24/2019 11:23 AM Updated by: thepinetree on 01/24/2019 11:23 AM
Expires: 01/01/2024 12:00 AM
:

Newly Published Research Points to Gum Disease as Potential Alzheimer's Cause

South San Francisco CA...Cortexyme, Inc., the privately held, clinical-stage pharmaceutical company developing therapeutics to alter the course of Alzheimer’s disease (AD) and other degenerative disorders, has announced publication of a foundational paper supporting its approach in Science Advances, a top-ranked multidisciplinary journal published by the American Association for the Advancement of Science (AAAS). In the paper, an international team of researchers led by Cortexyme co-founders Stephen Dominy, M.D. and Casey Lynch detail the role of a common bacterium, Porphyromonas gingivalis (Pg), in driving Alzheimer’s disease pathology and demonstrate the potential for small molecule inhibitors to block the pathogen.




“Infectious agents have been implicated in the development and progression of Alzheimer’s disease before, but the evidence of causation hasn’t been convincing,” said Stephen Dominy, M.D., Cortexyme co-founder, chief scientific officer, and lead author on the paper. “Now, for the first time, we have solid evidence connecting the intracellular, Gram-negative pathogen, Pg, and Alzheimer’s pathogenesis while also demonstrating the potential for a class of small molecule therapies to change the trajectory of disease.”

The Science Advances publication details how researchers identified Pg, the keystone pathogen in chronic periodontal disease, in the brains of patients with AD. In mouse models, oral Pg infection led to brain colonization and increased production of amyloid beta (Aβ), a component of the amyloid plaques commonly associated with Alzheimer’s.

In addition to Pg itself, the study team also detected the organism’s toxic proteases, or gingipains, in the neurons of patients with AD. The team correlated the gingipain levels with pathology related to two markers: tau, a protein needed for normal neuronal function, and ubiquitin, a small protein tag that marks damaged proteins for degradation and is found in tau tangles and Aβ plaques. The gingipains were found to be neurotoxic in vivo and in vitro, exerting detrimental effects on tau.

Seeking to block Pg-driven neurotoxicity, Cortexyme set out to design a series of small molecule therapies targeting Pg gingipains. In preclinical experiments detailed in the paper, the researchers demonstrated that inhibition by COR388, the most promising compound in the series and the subject of Cortexyme’s ongoing clinical development program, reduced the bacterial load of an established Pg brain infection, blocked Aβ42 production, reduced neuroinflammation, and protected neurons in the hippocampus, the part of the brain that mediates memory and frequently atrophies early in the development of AD.

“Despite significant funding and the best efforts of academic, industry, and advocacy communities, clinical progress against Alzheimer’s has been frustratingly slow,” said Casey Lynch, Cortexyme’s co-founder, chief executive officer, and an author on the Science Advances paper. “The Science Advances publication sheds light on an unexpected driver of Alzheimer’s pathology – the bacterium commonly associated with chronic gum disease – and details the promising therapeutic approach Cortexyme is taking to address it with COR388.”

In October 2018, Cortexyme announced encouraging results from its Phase 1b clinical trial of COR388 at the 11th Clinical Trials in Alzheimer’s Disease Conference. Investigators reported the compound was safe and well tolerated in healthy older volunteers and Alzheimer’s patients when given at a range of doses for up to 28 days. COR388 was detectable in the cerebral spinal fluid (CSF) along with fragmented DNA from the bacterium that COR388 targets. Additionally, while the study was not powered for significance, COR388 showed positive trends across several cognitive tests in patients suffering from AD. Cortexyme plans to initiate a large Phase 2/3 clinical trial of COR388 in mild to moderate AD in 2019.

Read the Science Advances paper in full here:

http://advances.sciencemag.org/content/5/1/eaau3333

About Cortexyme

Cortexyme is a privately held, clinical-stage pharmaceutical company developing therapeutics to alter the course of Alzheimer’s and other degenerative disorders. Cortexyme is targeting a specific, infectious pathogen tied to neurodegeneration and chronic inflammation in humans and animal models. The company’s lead compound, COR388, is entering Phase 2/3 development; additional proprietary small molecules are moving forward in preclinical development. Cortexyme’s investors include Sequoia Capital, Vulcan Capital, Verily Life Sciences, EPIQ Capital Group, RSL Investments, Lamond Family, Pfizer, Takeda Ventures, Breakout Ventures, Dolby Family Ventures, and Breakout Labs among others. For more information on Cortexyme, visit www.cortexyme.com.


Comments - Make a comment
The comments are owned by the poster. We are not responsible for its content. We value free speech but remember this is a public forum and we hope that people would use common sense and decency. If you see an offensive comment please email us at news@thepinetree.net
No Subject
Posted on: 2019-01-24 13:33:57   By: Anonymous
 
Brush your teeth or forget your name.

[Reply ]

    Really?
    Posted on: 2019-01-24 13:38:04   By: Anonymous
     
    I know plenty of people that didn't have peridontal infection, had all their teeth extracted in their 30's because of headaches, it was the rage then, or dentists wanted to sell extractions and dentures. Many did get Alzheimer.

    [Reply ]

      Re: Really?
      Posted on: 2019-01-24 15:16:08   By: Anonymous
       
      Funny, I don't know anyone who took care of their teeth who got them extracted. Such a very odd thing to do. The study's just a jumping off point - it's not saying this bacteria causes Alzheimers as much as the same one behind gingivitis was found in the brains of Alzheimers patients. So, there's a connection there with much more to be discovered.

      [Reply ]

        Re: Really?
        Posted on: 2019-01-24 19:59:01   By: Anonymous
         
        This disease is brought here by illegal immigrants.

        [Reply ]

          Re: Really?
          Posted on: 2019-01-24 20:43:04   By: Anonymous
           
          The blue dots are prettier, hence better, than the red dots.

          [Reply ]

            Re: Really?
            Posted on: 2019-01-24 22:24:30   By: Anonymous
             
            Gay red dots.

            [Reply ]

      Re: Really?
      Posted on: 2019-01-25 19:24:15   By: Anonymous
       
      Hey Melania. Gum this!!!!

      [Reply ]

    Truth is poison to Liberals
    Posted on: 2019-01-25 14:10:24   By: Anonymous
     

    Trump is doing it all by the book and by The Constitution. Congress still owns this 100%!!
    #pelosishutdown #schumershutdown #obstructionism #rejectdemocrats #rejectliberals #rejectsocialists #rejectprogressives #VoteThemOutIn2020 #rejectdaca #rejectillegals #bordersecuritynow #fundbordersecuritynow #Blexit #Lexit #NeverDemocrats
    Tick n Tock goes the Clock to see if we get Executive Order National Emergency #32 or not. We have 31 National Emergency Executive Orders active at this time dating back to the Carter Era.
    Step on the crack and break the Democrat's back.


    [Reply ]

No Subject
Posted on: 2019-01-24 13:58:05   By: Anonymous
 
Next will be if you MASTERBATE you will get Alzheimer's

[Reply ]

    Re:
    Posted on: 2019-01-24 14:49:44   By: Anonymous
     
    No, if you masturbate then you will go blind! If this article is true then over 90% of foothill residents will get Alzheimers Disease because of periodontal disease.

    [Reply ]

      Re:
      Posted on: 2019-01-24 15:17:12   By: Anonymous
       
      Try going back and reading more closely. It's a link so far - not a proven cause.

      [Reply ]

      Re:
      Posted on: 2019-01-24 15:22:14   By: Anonymous
       
      I need to shave the palms of my hands twice a day.


      [Reply ]

      Everytime you masturbate,
      Posted on: 2019-01-24 20:40:14   By: Anonymous
       
      God kills a kitten.

      [Reply ]

        Masturbation
        Posted on: 2019-01-24 20:46:51   By: Anonymous
         
        causes global warming, & illegal immigration!

        [Reply ]

      Re:
      Posted on: 2019-01-25 19:25:10   By: Anonymous
       
      I should have been blind 60 years ago!

      [Reply ]

HA!!! Damn Democratic Tweakers
Posted on: 2019-01-24 15:29:42   By: Anonymous
 

Well that explains why there's not many democrats up here. All the Tweakers forgot who they were and stopped voting after snorting or eating their poison.

[Reply ]


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