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Posted by: thepinetree on 01/02/2018 10:31 PM Updated by: thepinetree on 01/02/2018 10:31 PM
Expires: 01/01/2023 12:00 AM
:

Diabetes Drug 'Significantly Reverses Memory Loss' in Mice with Alzheimer's

Lancaster, UK...A drug developed for diabetes could be used to treat Alzheimer's after scientists found it "significantly reversed memory loss" in mice through a triple method of action. The research, published in Brain Research, could bring substantial improvements in the treatment of Alzheimer's disease through the use of a drug originally created to treat type 2 diabetes. Lead researcher Professor Christian Holscher of Lancaster University in the UK said the novel treatment "holds clear promise of being developed into a new treatment for chronic neurodegenerative disorders such as Alzheimer's disease."




Alzheimer's disease is the most common cause of dementia and the numbers are expected to rise to two million people in the UK by 2051 according to Alzheimer's Society, who part- funded the research.

Dr Doug Brown, Director of Research and Development at Alzheimer's Society, said: ""With no new treatments in nearly 15 years, we need to find new ways of tackling Alzheimer's. It's imperative that we explore whether drugs developed to treat other conditions can benefit people with Alzheimer's and other forms of dementia. This approach to research could make it much quicker to get promising new drugs to the people who need them."

Although the benefits of these 'triple agonist' drugs have so far only been found in mice, other studies with existing diabetes drugs such as liraglutide have shown real promise for people with Alzheimer's, so further development of this work is crucial."

This is the first time that a triple receptor drug has been used which acts in multiple ways to protect the brain from degeneration. It combines GLP-1, GIP and Glucagon which are all growth factors. Problems with growth factor signalling have been shown to be impaired in the brains of Alzheimer's patients.

The study used APP/PS1 mice, which are transgenic mice that express human mutated genes that cause Alzheimer's. Those genes have been found in people who have a form of Alzheimer's that can be inherited. Aged transgenic mice in the advanced stages of neurodegeneration were treated.

In a maze test, learning and memory formation were much improved by the drug which also:-

enhanced levels of a brain growth factor which protects nerve cell functioning
reduced the amount of amyloid plaques in the brain linked with Alzheimer's
reduced both chronic inflammation and oxidative stress
slowed down the rate of nerve cell loss
Professor Holscher said: "These very promising outcomes demonstrate the efficacy of these novel multiple receptor drugs that originally were developed to treat type 2 diabetes but have shown consistent neuro- protective effects in several studies."

"Clinical studies with an older version of this drug type already showed very promising results in people with Alzheimer's disease or with mood disorders"

"Here we show that a novel triple receptor drug shows promise as a potential treatment for Alzheimer's but further dose-response tests and direct comparisons with other drugs have to be conducted in order to evaluate if this new drugs is superior to previous ones."

Type 2 diabetes is a risk factor for Alzheimer's and has been implicated in the progression of the disease. Impaired insulin has been linked to cerebral degenerative processes in type 2 diabetes and Alzheimer's disease. Insulin desensitisation has also been observed in the Alzheimer's disease brain. The desensitisation could play a role in the development of neurodegenerative disorders as insulin is a growth factor with neuroprotective properties.

###


Comments - Make a comment
The comments are owned by the poster. We are not responsible for its content. We value free speech but remember this is a public forum and we hope that people would use common sense and decency. If you see an offensive comment please email us at news@thepinetree.net
No Subject
Posted on: 2018-01-02 23:18:22   By: Anonymous
 
I want a crenellated haircut.

[Reply ]

    Re: Huh?
    Posted on: 2018-01-03 21:44:59   By: Anonymous
     
    Did I read this article earlier?
    It's so hard to tell sometimes.

    [Reply ]

      Re: Huh?
      Posted on: 2018-01-03 21:45:29   By: Anonymous
       
      Did I read this article earlier?
      It's so hard to tell sometimes.

      [Reply ]

        Re: Huh?
        Posted on: 2018-01-03 21:46:00   By: Anonymous
         
        Did I read this article earlier?
        It's getting so hard to tell sometimes.

        [Reply ]

          Re: Huh?
          Posted on: 2018-01-03 21:46:40   By: Anonymous
           
          Did I read this article earlier?
          It's getting harder to tell all the time.

          [Reply ]

The Mind
Posted on: 2018-01-03 00:26:17   By: Anonymous
 
Is a terrible thing.

[Reply ]

    Re: The Mind
    Posted on: 2018-01-03 06:42:05   By: Anonymous
     
    For all this time I thought it was cannabis. I guess its just the growers that are blowing smoke up our keisters.

    [Reply ]

      Re: The Mind
      Posted on: 2018-01-03 07:06:08   By: Anonymous
       
      Are you that drunk you let someone blow smoke up your keister?
      You're sick.

      [Reply ]

        Re: The Mind
        Posted on: 2018-01-03 21:47:48   By: Anonymous
         
        You aughta see what's in This keister.

        [Reply ]

No Subject
Posted on: 2018-01-03 07:37:11   By: Anonymous
 
Type 2 diabetes is on the rise in our country and in part brought on by a bad diet and obesity. Aside from the age factor, an't help but wonder if we are going to find a connection with being overweight with Alzheimer's and dementia.

[Reply ]

    Re:
    Posted on: 2018-01-03 08:57:03   By: Anonymous
     
    You say somebody could actually reduce their chance of getting Alzheimer's by simply not shoving so much food in their face? Shocking, who knew?

    Next thing you know they'll start claiming that there are other heath benefits to exercise and moderation in food intake.

    Maybe we could develop that concept into a national health policy. Or we could just continue to pay billions to the pharmaceutical companies to develop drugs to offset the effects of our bad habits.

    [Reply ]

      Re:
      Posted on: 2018-01-03 09:06:18   By: Anonymous
       
      Original poster here. Thank you and could not agree more.

      [Reply ]

      Re:
      Posted on: 2018-01-03 09:51:51   By: Anonymous
       
      No question that exercise and a good diet support good health.

      But I've known 3 people who developed Alzheimer's Disease and none were overweight or couch potatoes. It would be very cruel and wrong to blame someone with Alzheimer's Disease for having the disease, even if they were fat and lazy. It's a terrible disease and it is not the fault of those afflicted.

      As for pharmaceutical companies making billions, I give them my thanks for saving many lives, including mine. People live longer because there are antibiotics to treat infections we used to die of, drugs to treat high blood pressure, and so many other conditions. They make money just like every other successful business. American capitalism at its best.

      I will agree there are some bad actors that charge ridiculous prices for old drugs. That may be capitalism too but it is immoral and should be illegal.

      [Reply ]

No Subject
Posted on: 2018-01-03 07:38:24   By: Anonymous
 
Any advance in Alzheimer's treatment is great news. If you have ever known someone affected with that disease, you know how devastating it is to patients and their loved ones. But this approach will probably apply only to the inherited form of Alzheimer's, which is not what most patients have. It's still great news.

[Reply ]

    Re:
    Posted on: 2018-01-03 21:50:13   By: Anonymous
     
    Just read your post and if you have ever known of any advance in Alzheimer's treatment it would be great news. Please share.

    [Reply ]

No Subject
Posted on: 2018-01-03 09:52:50   By: Anonymous
 
The picture accompanying this story is great. It perfectly captures the disease.

[Reply ]

    Re:
    Posted on: 2018-01-03 11:22:51   By: Anonymous
     
    and reminds me to buy firewood


    [Reply ]

      Re:
      Posted on: 2018-01-03 13:02:21   By: Anonymous
       


      [Reply ]

        Re:
        Posted on: 2018-01-03 17:00:46   By: Anonymous
         
        Tucked behind palm trees on an oceanfront lot, Villa Oceanis is a perfect romantic hideaway or family vacation spot in Guanacaste. Enjoy the sound of the waves from the villa’s pool and outdoor living area or simply cross the lawn to the ocean. Though the two-bedroom house is secluded and private, it’s also just 80 minutes from the Liberia airport.
        Start each day with coffee at the outdoor dining area on the sun-dappled deck facing the ocean, then adjourn to the deck’s lounge area or the pool, which has a jetted seating area. The ocean lies down a flight of steps from the lawn, and you’ll find snorkeling equipment at the villa. While away the afternoon in the hammocks or daybed, rinse off in the outdoor shower and prep dinner on the gas grill. Satellite TV and Wi-Fi ensure you’ll stay entertained in the evenings, and air-conditioned bedrooms ensure you’ll stay comfortable.
        The villa is cozy yet beachy, with light filtering through the palm trees onto wood floors and white and gray paneled walls. Floor-to-ceiling sliding glass doors open to the oceanfront deck on one side and the lush garden on the other. The open-plan living room, dining room and kitchen has a wall of built-in wood cabinets, a plush gray sectional and a round dining table. Accents like turquoise throw cushions and a blue backsplash bring the colors of the ocean inside.
        Each of the villa’s two bedrooms has an en-suite bathroom with shower, air conditioning and a ceiling fan. One bedroom has a queen bed, and the other has a full bed and twin bunk bed. Like the common areas, the bedrooms are breezy and welcoming, with whitewashed beamed ceilings, rustic paneled walls, and colorful modern artwork.
        Villa Oceanis is a 200-meter walk from Playa Blanca. By car, it’s 5 minutes to a grocery store and Playa Negra, 10 minutes to a church, 30 minutes to the Pinilla Golf Course, 40 minutes to a tennis court and the town of Tamarindo and 45 minutes to the town of Santa Cruz. The Liberia airport is an 85-minute drive away.
        Copyright © Luxury Retreats. All rights reserved.


        Bedroom / Bathroom Description

        Bedroom 1
        Queen size bed, En-suite bathroom with shower, Air conditioning, Ceiling fan, Safe

        Bedroom 2
        Twin bunk bed, Full size bed, En-suite bathroom with shower, Air conditioning, Ceiling fan

        Features & Amenities
        Child friendly villa
        Air conditioned bedrooms
        Ceiling fan
        Satellite TV
        DVD player
        CD player
        iPod dock
        Wi-Fi access
        Telephone
        Baby equipment
        Washer/dryer (separate from main house)
        Iron
        Kitchen:
        Blender
        Toaster
        Microwave
        Refrigerator/freezer
        Ice maker
        Coffee maker
        Dishwasher
        Outdoor Features
        Oceanfront
        Swimming pool
        Jetted seating area
        Alfresco shower
        Outdoor furniture
        Alfresco dining
        Gas grill
        Hammocks
        Daybed
        Snorkeling equipment
        Parking
        Staff & Services
        Included:
        Gardener
        Daily housekeeping (2 hours a day except Sundays)
        Villa manager
        24/7 private on-site concierge
        At Extra Cost – advance notice may be required:
        Villa pre-stocking
        Activities and excursions
        Airport transfer
        Cook service
        Driver service
        Villa Policies
        Maximum 4 guests
        Children welcome
        Non-smoking villa
        Pets not permitted
        Social events permitted upon request only. Bachelor parties are strictly prohibited
        No unregistered guests permitted unless approval is given
        Getting There
        4x4 rental vehicle recommended
        Transport available
        Location
        200 meters to Playa Blanca beach
        3 minute walk to Iguanazul Restaurant
        5 minute drive to grocery store and Playa Negra
        10 minute drive to church
        30 minute drive to Pinilla Golf Course
        40 minute drive to Tamarindo and tennis club
        45 minute drive to town of Santa Cruz
        80 minute drive to Liberia Airport

        [Reply ]

          Re: Whoopee!
          Posted on: 2018-01-03 21:56:29   By: Anonymous
           
          Luxury Resorts has provided many venues for us to do Black Ops training. Villa Oceanis is a perfect spot because the poor local villagers are afraid to report auto gunfire and explosions in their poorer neighborhoods.
          If you want a place for casual violence, contact Luxury Resorts, they give you more Boom for the Bang!
          Just ask for the "Black Out Big Fun" package.

          [Reply ]


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